What disorder is an example of an autosomal recessive condition?

What disorder is an example of an autosomal recessive condition?

• A. Marfan syndrome
• B. Huntington's disease
• C. Sickle cell anemia
• D. Hemophilia

Answer: (C)

Sickle cell anemia is an example of an autosomal recessive condition because it requires two copies of the mutated gene for the disorder to manifest. This means that an individual must inherit one copy of the sickle cell gene from each parent in order to exhibit symptoms of the disease. Sickle cell anemia occurs due to a mutation in the HBB gene, which encodes the beta-globin subunit of hemoglobin. When both alleles are mutated, the resulting hemoglobin leads to sickle-shaped red blood cells, causing various health complications. In contrast, disorders like Marfan syndrome and Huntington's disease are typically associated with autosomal dominant inheritance, where only one mutated allele from an affected parent can result in the disorder. Hemophilia is often linked to an X-linked recessive pattern, primarily affecting males and requiring two copies of the mutated gene in females. These distinctions help in understanding the genetic mechanisms behind each condition.

Sickle cell anemia is an example of an autosomal recessive condition because it requires two copies of the mutated gene for the disorder to manifest. This means that an individual must inherit one copy of the sickle cell gene from each parent in order to exhibit symptoms of the disease. Sickle cell anemia occurs due to a mutation in the HBB gene, which encodes the beta-globin subunit of hemoglobin. When both alleles are mutated, the resulting hemoglobin leads to sickle-shaped red blood cells, causing various health complications.

In contrast, disorders like Marfan syndrome and Huntington's disease are typically associated with autosomal dominant inheritance, where only one mutated allele from an affected parent can result in the disorder. Hemophilia is often linked to an X-linked recessive pattern, primarily affecting males and requiring two copies of the mutated gene in females. These distinctions help in understanding the genetic mechanisms behind each condition.